amcHydroFlow--American Membrane Corporation

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FILTER MEDIA

amcHydroFlow

amcHydroFlow cartridge is a filter specifically designed for reduction of bioburden and particulate levels to protect final 0.1 and 0.2 μm system filters. The filter medium is amcAccupor membrane, i.e., modified polyethersulfone hydrophilic membrane developed by AMC for various applications.

amcHydroFlow cartridge is designed for low cost, higher throughput than Nylon, PVDF, or cellulose esters membrane cartridges.

Performance Advantages

Constructed of only two materials, i.e., modified polyethersulfone and polypropylene with no adhesives to ensure lower extractables
All components meet USP Class VI-121°C Plastics Tests for biosafety, and are listed as being acceptable for food contact applications according to the Code of Federal Regulations, Title 21
Provides faster flow rate and higher throughput than nylon, PVDF or cellulose esters membrane filters
Reduced microbial bioburden and particulate levels to protect final filters
Available in a variety of configurations allowing for easy installation in commonly used filtration systems

Typical Applications

Parenterals, ophthalmics, oral and topical medicines, serum, tissue culture media, wash and rinse water, diagnostic reagents, buffers,vaccines, bottle and vial washers, make-up water

Materials of Construction
Filter Media:	Single layer of pleated amcAccupor membrane (modified hydrophilic PES membrane)
Support Material:	Polypropylene
Structure Components:	Polypropylene
Sealing Technology:	Thermal bonding

Dimensions
Nominal Length:	10, 20, 30, and 40 inch (25.4, 50.8, 76.2, and 101.6 cm)
Diameter:	2.7 inches (6.9 cm)

Nominal Pore Sizes	0.2, 0.45, 0.8 μm

Typical Effective Filtration Area	7 ft² (0.65 m²) per 10 inch

Maximum Operating Temperature	85°C (185°F) at 30 psi (2.1 bar)
(Supported adapters are recommended for applications at elevated temperature over 60°C)

Sterilization/Sanitization Methods
Chemical:	Peracetic acid, chlorinated alkaline products, bleach, sulfur dioxide, and hydrogen peroxide at typical sanitization concentrations and temperatures
Hot Water:	88°C (190°F) at 5 psi (0.3 bar)
Autoclave:	121°C (250°F) for 30 minutes up to 30 cycles
In-line Steam:	140°C (284°F) for 60 minutes at 2 psi (0.14 bar) up to 15 cycles

Maximum Differential Forward Pressure	0.2 μm, 0.45 μm: 60 psi (4.1 bar) at ambient temperature 0.8 μm: 50 psi (3.4 bar) at ambient temperature

Maximum Differential Back Pressure	15 psi (1.0 bar) at ambient temperature

Recommended Integrity Tests

Minimum Bubble Point:	0.2 μm: 45 psi (3.1 bar) in water 0.45 μm: 28 psi (1.9 bar) in water 0.8 μm: 10 psi (0.7 bar) in water

Diffusional Flow in Water:	Provided separately*

Typical Water Flow Rate	0.2 μm: 3 gpm/psi/10 inch (6.5 lpm/0.1 bar/25.4 cm length) 0.45 μm: 5.2 gpm/psi/10 inch (28.5 lpm/0.1 bar/25.4 cm length) 0.8 μm: 10 gpm/psi/10 inch (54.9 lpm/0.1 bar/25.4 cm length)

Oxidizable Substances	Filtrate meets USP XXII requirements for purified water with <1 L flush after autoclaving

Biosafety	Materials pass USP Class VI-121°C Plastics Tests, and are listed as being acceptable for food contact according to the Code of Federal Regulations, Title 21

Endotoxin Level	<0.25 EU/ml utilizing Limulus Amoebocyte Lysate (LAL) test

Typical Water Flow Rate

amcHydroFIow Water Flow Rate

Ordering Information H F ■ ■ F ◆ ● ▲
■ Rated Pore Size	20	0.2 μm
	45	0.45 μm
	80	0.8 μm

◆ Nominal Length	1	10 inch (25.4 cm)
	2	20 inch (50.8 cm)
	3	30 inch (76.2 cm)
	4	40 inch (101.6 cm)

● Cartridge Configuration	D	SOE, Flat
	F	DOE, Gasket/Gasket 10 inch increments
	J	SOE, -222/Flat/SS*
	K	SOE, -222/Fin/SS*
	M	SOE, -222/Flat
	P	SOE, -222/Fin
	Q	SOE, -226/Fin
	R	SOE, -226/Fin/SS*
	V	SOE, -226/Flat
	W	SOE, -226/Flat/SS*

▲ Seal Material	S	Silicone
	V	Viton
	E	Ethylene Propylene

amcHydroFlow.pdf