amcAccuFlow HP--American Membrane Corporation

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FILTER MEDIA

amcAccuFlow HP

amcAccuFlow HP cartridge is a premium sterilizing-grade filter product combining two layers of amcAccupor membrane with thermally bonded polypropylene components to provide a durable filter for aggressive microfiltration applications. Its double layer membrane configuration makes the cartridge ideally suited for final filtration in critical applications, especially those involving fluids at high temperatures.

amcAccuFlow HP cartridge is manufactured under tightly controlled procedures for consistent and reliable performance. During manufacturing, each amcAccuFlow HP cartridge is flushed with proprietary solvents, followed by purified water, and integrity tested to ensure product quality.

amcAccuFlow HP cartridge is compatible with multiple autoclave and in-line steam sterilization, as well as chemical sanitization methods.

Performance Advantages

Constructed of only two materials, i.e., modified polyethersulfone and polypropylene with no adhesives to ensure lower extractables
Manufactured under stringent processes to ensure highest level of quality and consistency
Provides high particle retention to minimize filter change-outs during batch processing
Maximizes recovery of critical solution components with amcAccupor PES membrane's extensive drug compatibility and low protein binding characteristics
Offers great resistance to severe sanitizing agents such as hot water, concentrated hydrogen peroxides, and active chloride compounds
100% integrity tested in production to ensure optimal quality product

Typical Applications

Parenterals, ophthalmics, oral and topical medicines, serum, tissue culture media, wash and rinse water, diagnostic reagents, buffers,vaccines, bottle and vial washers, make-up water

Materials of Construction
Filter Media:	Two layers of pleated amcAccupor membrane (modified hydrophilic PES membrane)
Support Material:	Polypropylene
Structure Components:	Polypropylene
Sealing Technology:	Thermal bonding

Dimensions
Nominal Length:	10, 20, 30, and 40 inch (25.4, 50.8, 76.2, and 101.6 cm)
Diameter:	2.7 inches (6.9 cm)

Nominal Pore Sizes	0.1, 0.2 μm

Typical Effective Filtration Area	5.8 ft² (0.54 m²) per 10 inch

Maximum Operating Temperature	90°C (194°F) at 30 psi (2.1 bar)
(Supported adapters are recommended for applications at elevated temperature over 60°C)

Sterilization/Sanitization Methods
Chemical:	peracetic acid, chlorinated alkaline products, bleach, sulfur dioxide, and hydrogen peroxide at typical sanitization concentrations and temperatures
Autoclave:	121°C (250°F) for 30 minutes up to 50 cycles
In-line Steam:	121°C (250°F) for 60 minutes at 2 psi (0.14 bar) up to 50 cycles 142°C (288°F) for 60 minutes at 2 psi (0.14bar) up to 25 cycles

Maximum Differential Forward Pressure	60 psi (4.1 bar) at ambient temperature

Maximum Differential Back Pressure	0.1 μm: 30 psi (2.1 bar) at ambient temperature 0.2 μm: 15 psi (1.0 bar) at ambient temperature

Maximum Continuous Pressure	Limited by housing

Recommended Integrity Tests

Minimum Bubble Point:	0.1 μm: 28 psi (2.0 bar) in ethanol 0.2 μm: 49 psi (3.4 bar) in water

Diffusional Flow in Water:	Provided separately*

Typical Water Flow Rate	0.1 μm: 0.2 gpm/psi/10 inch length (1.1 lpm/0.1 bar/25.4 cm length) 0.2 μm: 1.2 gpm/psi/10 inch length (6.6 lpm/0.1 bar/25.4 cm length)

Oxidizable Substances	Filtrate meets USP XXII requirements for purified water with <1 L flush after autoclaving

Biosafety	All components meet USP Class VI-121°C Plastics Tests, and are listed as being acceptable for food contact accoding to the Code of Federal Regulations, Title 21

Endotoxin Level	<0.25 EU/ml utilizing Limulus Amoebocyte Lysate (LAL) test

Typical Non-Volatile Residue	50 ppm per 10 inch

Bacterial Retention	Provided Upon Request

Typical Water Flow Rate

amcAccuFlow HP Water Flow Rate

Ordering Information A F ■ ■ H ◆ ● ▲
■ Rated Pore Size	10	0.1 μm
■ Rated Pore Size	20	0.2 μm

◆ Nominal Length	1	10 inch (25.4 cm)
	2	20 inch (50.8 cm)
	3	30 inch (76.2 cm)
	4	40 inch (101.6 cm)

● Cartridge Configuration	D	SOE, Flat
	F	DOE, Gasket/Gasket 10 inch increments
	J	SOE, -222/Flat/SS*
	K	SOE, -222/Fin/SS*
	M	SOE, -222/Flat
	P	SOE, -222/Fin
	Q	SOE, -226/Fin
	R	SOE, -226/Fin/SS*
	V	SOE, -226/Flat
	W	SOE, -226/Flat/SS*

▲ Seal Material	S	Silicone
	V	Viton
	E	Ethylene Propylene

amcAccuFlow HP.pdf